A dipeptide isolated from the dental vector <i>Porphyromonas gingivalis</i> has been shown to be a factor in triggering multiple sclerosis in mice. We have tentatively identified this lipid as the known dipeptide flovonlipin. We have synthesized this compound by a convergent route that allows us to identify each steroisomer, with the goal of correlating the interesting bioactivity with the correct stereoisomer. We present the synthetic route and the structure of the bioactive compound, with supporting biological data.

Synthesis and structure proof for a bioactive lipid associated with multiple sclerosis, isolated from <i>Porphyromons gingivalis</i>

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Synthesis and structure proof for a bioactive lipid associated with multiple sclerosis, isolated from Porphyromons gingivalis