We report a new simple, inexpensive and one-step fabrication method for microfluidic paper-based analytical device (mPAD) fabrication that requires only polystyrene and a patterned screen. The polystyrene solution applied through the screen penetrates through the paper forming a three dimensional hydrophobic barrier, defining a hydrophilic analysis zone. The proposed mPAD fabrication provides fast and mass production, can create various patterns on the mPAD and give high resolution and reproducibility of the mPAD features making it useful alternative to current mPAD fabrication method. The fabricated mPAD was demonstrated as a novel, simple paper-based sensor combining with instrument-free distance-based detection with CeO2 nanoparticles as colorimetric probes for H2O2 analysis and validated with the traditional KMnO4 titration. We also applied the fabricated mPAD for the proof-of-concept analysis of antioxidant activity.

Polymer screen-printing for paper-based device fabrication

249th National Meeting (2015)

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