Mixed-metal Supramolecular complexes with photo-induced DNA modification can be used as potential PDT (photodynamic therapy) agents.1 The Ru-Rh bimetallic complexes of the design [(TL)2Ru(BL)Rh(TL)X2]3+(TL = terminal ligand; BL = bridging ligand; X= labile ligand) exhibit visible light induced DNA photobinding and oxygen independent photocleavage.2 However, cellular uptake and photocytotoxicity of these bimetallic complexes remain unexplored. Variation of the TL on the PS (photosensitizer) moiety provides insight into the relationship between structure and biological activity. Uptake of Ru-Rh bimetallic complexes towards rat malignant glioma F98 cells was determined by ICP-MS. The light-activated antiproliferative activity of supramolecular Ru-Rh complexes was directly tested against F98 MG cell line. Low cytotoxicity was observed for the treatment of cells with metal complexes under dark conditions. Significant photocytotoxicity and cell growth inhibition were established with the treatment of metal complex under photolysis. Acknowledgement is made to VT ICTAS 119552 and the National Science Foundation 478898 for their generous funding. 1. Wang, J.; Newman, J.; Higgins, S. L. H.; Brewer, K. M.; Winkel, B. S. J.; Brewer, K. J., Red-Light-Induced Inhibition of DNA Replication and Amplification by PCR with an Os/Rh Supramolecule. Angew Chem Int Edit 2013, 52 (4), 1262-1265. 2. Wang, J.; Zigler, D. F.; Hurst, N.; Othee, H.; Winkel, B. S. J.; Brewer, K. J., A new, bioactive structural motif: Visible light induced DNA photobinding and oxygen independent photocleavage by Ru-II, Rh-III bimetallics. Journal of Inorganic Biochemistry 2012, 116, 135-139.

Exploring the cellular activity of polyazine bridged Ru(II)-Rh(III) supramolecules in rat malignant glioma F98 cells

249th National Meeting (2015)

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