We have used thiosemicarbazones and [(aryl)hepta-1,6-diene-3,5-dione]s (curcuminoids), as ligands in the synthesis of organometallic ruthenium complexes of the type [(η6-arene)Ru(ligand)Cl] where arene = benzene, p-cymene or 1,4,7-trithiacyclononane ([9]aneS3). The thiosemicarbazone ligands were derived from piperonal and 9-anthraldehyde while the curcuminoids were synthesized from dimethylaminobenzaldehyde and ferrocene carbaldehyde. The complexes have been characterized by elemental analyses and spectroscopic methods. The interaction of the thiosemicarbazone complexes with topoisomerase II have been investigated by gel electrophoresis and molecular docking. The curcuminoid complexes have been investigated by molecular modelling. Initial biophysical studies investigations of reactions with DNA have also been carried out.

Biochemical and molecular modelling studies of the interaction of organometallic ruthenium complexes containing thiosemicarbazones or curcuminoids as ligands with DNA and proteins

249th National Meeting (2015)

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