A concurrent tandem catalytic methodology for the amidation of aryl halides are under investigation. The process starts with a halide exchange reaction to form aryl iodides from less reactive aryl chlorides and aryl bromides. In a subsequent step, the aryl iodide intermediate is consumed as the substrate for the C-N bond-forming reaction. Optimized conditions for the transformation (metal/ligand loading, solvent, base, reaction time, temperature) will be presented as well as the substrate scope for this methodology. Evidence that the reaction is occurring via a concurrent tandem catalytic mechanism will be discussed.

Microwave-assisted concurrent tandem catalysis (CTC) methodology for the copper-catalyzed amidation of aryl halides

249th National Meeting (2015)

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