Oleandrin, which is found in the plant Nerium oleander, is known to induce fatal poisoning by ingestion of small quantities; however, this cardiac glycoside is also known for its medical and toxicological properties that make it useful in treating heart failure and cardiac arrhythmia. We have developed a new class of supported metal ion solid-phase extraction resins to isolate oleandrin in high purity from N. oleander, utilizing fewer and less hazardous solvents and accompanied with a factor of 3 time savings over published liquid-liquid extraction methods from plant tissue. We demonstrate quantitative recovery and observed improved selectivity with calcium- and copper(II)-modified resins, as compared to commercially-available unmodified resins. We also present results showing a further improvement in extraction time using microwave-assisted extraction. Work is on-going to expand the applicability of this new class of resins to other glycosides.

Solid-phase extraction using new divalent metal ion-loaded cation exchange resins and application to the isolation of oleandrin from Nerium oleander

249th National Meeting (2015)

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