Gold-containing catalysts have emerged over the past decade as an important tool for the construction of complex organic structures. Cationic gold complexes are robust, versatile, selective and efficient catalysts that can be used in the formation of C-C and C-X bonds, often in conjunction with the activation of C-C pi-systems for nucleophilic attack. We investigated the activation of allyl aryl ether moieties for intramolecular attack of an oxygen nucleophile to prepare cyclic ethers and lactones. A sterically bulky, electron-withdrawing substituent on the allylic oxygen leaving groups improved reaction efficiency and diastereoselectivity using gold(III) catalysts.<br/>

Gold-catalyzed synthesis of cyclic ethers and lactones

249th National Meeting (2015)

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