We investigate the effect of monomer sequence on the uptake of polymeric chains by cells. Four configurations of the monomers <i>N</i>-acryloylmorpholine, 2-hydroxyethylacrylamide, <i>N,N</i>-dimethylacrylamide were investigated to determine if uptake could be promoted or hindered by an appropriate selection of polymeric architecture. Our findings show that re-arrangement of the monomer sequences results in a significant difference in uptake behaviour depending on individual block sequence or randomness. The insights gained will prove useful in the rational design of effective polymeric drug delivery systems.

To randomize or not to randomize: An investigation into the cell-uptake of polymers

249th National Meeting (2015)

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