The butenolide and 5-hydroxybutenolide are common moieties found in a variety of synthetically useful compounds, several natural products, and drugs with diverse biological activities. As part of on-going project to discover new antibacterial compounds, several 4-alkyl and 4-aryl-5-hydroxybutenolides have been synthesized and tested against a variety of bacterial strains. This study has revealed key structural features in butenolide containing compounds necessary for bacterial growth inhibition.

Antibacterial activity of 4-alkyl and 4-arylbutenolides

249th National Meeting (2015)

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