Hydrogen Sulfide (H2S) has been subject of great interest since the discovery of its role as an important signaling molecule in biological systems. It has been shown that H2S and its derivatives (such as HS−) are capable of reacting with the metal centers in heme containing proteins. In order to understand the mechanisms of these interactions in greater detail, we have prepared a variety of synthetic iron porphyrinate species and investigated their reactions with H2S, HS−, and other sulfur-containing molecules. The chemistry of H2S with both iron(II) and iron(III) porphyrinate systems will be discussed along with reactions of other biologically important small molecules such as nitric oxide.

Fundamental reactivity studies of hydrogen sulfide with metalloporphyrins

249th National Meeting (2015)

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