The development of high-yielding and efficient methods to synthesize complex products from simple starting materials through tandem or domino processes is appealing for industry. This can reduce step-counts in the synthesis of complex targets, while reducing costs and waste streams. We have developed a series of Lewis acid catalyzed tandem cyclization reactions of alkyne starting materials to generate functionalized 6-6-bicyclic and 6-5-6 tricyclic products in a one-pot process in good yields. In this reaction we are generating 4 to 5 new carbon-carbon bonds, 2 or 3 rings, and vicinal quaternary centers.

One-pot tandem cyclization of alkynes to generate polycyclic products

249th National Meeting (2015)

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