To increase our knowledge of RNA structure-function relationships, there is a need for new RNA probes. Novel compounds can be used to better understand ligand-RNA binding interactions with future medicinal and experimental applications. With that goal in mind, this project involved the synthesis and characterization of various platinum complexes with sulfur-containing amino acid ligands. These compounds will later be used in DNA and RNA binding studies. The compounds were synthesized with potassium tetrachloroplatinate and amino acids, Met or Cys, as starting materials. The conditions were varied such as the molar ratio of metal to ligand. The products were characterized by using NMR and IR spectroscopy. During the course of this project, certain challenges were met and overcome with alternative strategies, such as the ligand choice and experimental conditions.<br/>

Platinum(II) complexes with sulfur-containing peptide building blocks for use in RNA binding studies

249th National Meeting (2015)

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