Liposomes, spherical bilayer vesicles formed by dispersion of certain polar lipids in aqueous solvents, have attracted considerable attention in the food and agricultural industries in recent years because of their ability to act as targeted release-on-demand carrier systems for both water- and oil-soluble functional compounds such as antimicrobials, flavors, antioxidants, and bioactive ingredients. Encapsulation of functional components in liposomes has been shown to increase their stability and maintain their activity in environments that typically lead to rapid degradation. On the other hand, one of the major limitations of liposomes is that they have a tendency to leak and lose encapsulated components over time. Previous studies had demonstrated that adsorption of a second layer of polymer around the liposomes by electrostatic deposition, has been shown to be very effective at improving the stability of emulsions, could improve the stability of liposomes and provide an inexpensive means to tailor the surface properties of liposomes. In a previous work we have been shown the effect of coating soybean lecithin liposomes with chitosan biopolymer, via ionotropic gelation mechanism based on electrostatic interactions. In the present work, we will show for the first time, the effects of an electrostatic stabilization of liposomes using a natural polymeric coating agent, based on chitosan-tannin composites, that will work either as a coating agent, but also as a potential delivery system for active compounds, such as proteins and drugs. S. Madrigal-Carballo, S. Lim, G. Rodríguez, A.O. Vila, C.G. Krueger, S. Gunasekaran, J.D. Reed. J. Functional Foods, 2010, 2, 99. J.D. Reed, C.G. Krueger, S. Madrigal-Carballo. Tannin-Chitosan composites. USPTO, 2014, US 8,642,088 B2. Acknowledgments: Authors are deeply thankful to the Wisconsin Alumni Research Foundation (WARF) for the financial support for this research.

Secondary liposomes stabilized by the electrostatic deposition of chitosan-tannin composites as potential delivery systems for proteins

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.