Thio-sugars are biologically active with many important effects, pharmacologically distinctive from their oxygen analogs. Additionally, they possess some biological properties that made them potentially useful in cancer therapy as they are insensitive to carbohydrates degrading enzymes. We demonstrated earlier, that mono- and di-thio-sugars are cytotoxic on Hela cell line [1]. In the present study, our model thio-sugars showed the ability to sensitize HeLa cells to bleomycin treatment. More inspiringly, those thio-sugars markedly enhanced the antitumor activity of ROS in HeLa cells. Tert-Butyl hydroperoxide (t-BuOOH) was employed as ROS generator. Compared to treatment with bleomycin and t-BuOOH alone, treatment with combination of thio-sugars and bleomycin/ t-BuOOH remarkably inhibited the growth of Hela cells. Our study has identified specifically functionalized thio-sugars as a promising sensitizer for cancer chemotherapy. Acknowledgement This work was supported by the National Science Centre, decision nr DEC-2011/01/B/NZ4/03391 [1]. A Potential CARB-pharmacophore for antineoplastic activity. Part I. Z. J. Witczak, T. Poplawski A. Czubatka, J. Sarnik, P. Tokarz, A. L. VanWert, R. Bielski, Bioorganic & Med. Chem. Lett., 2014, 24, 1752-1757

Thio-sugars can sensitize human cervixadenocarcinoma (Hela) cancer cells to Bleomycin and ROS generator

249th National Meeting (2015)

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