N,O-chelating ligands such as amidates, ureates, phosphoramidates and pyridonates can adopt a variety of binding modes, including κ<sup>1</sup>, κ<sup>2</sup> and bridged species. Such variability in coordination modes can be observed for various early and late transition metal centers of catalytically active metals including C-H alkylation chemistry by hydroaminoalkylation. Hydroaminoalkylation is an emerging catalytic hydrofunctionalization reaction which assembles selectively substituted amines in a 100% atom-economic reaction from simple amines and alkenes.  Recent advances in the characterization of various binding modes and evidence supporting their role in realizing improved catalytic outcomes will be presented.  By taking advantage of the novel reactivity trends observed with these systems, the efficient synthesis of selectively substituted amines and amine containing materials will be showcased.

Hemilabile N,O-chelating ligands: Dynamic coordination modes for promoting reactivity and hydroaminoalkylation catalysis

249th National Meeting (2015)

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