The modern drug discovery scientist is bathed in structural information. Crystal structures of molecular targets can now be determined for almost every target class, often with ligands of interest. Many a drug discovery story tells of the involvement of structure-based drug design. But even more pervasive is the role of small molecule crystal structures. So much so, that the contribution of structural chemistry to drug discovery programs often goes unnoticed.<br/> <br/>This presentation, timed to coincide with the 50<sup>th</sup> anniversary of the Cambridge Structural Database will outline the immense contribution structural chemistry has made, and can make, to affinity optimisation, selectivity tuning, SAR determination, solubility enhancement, isostere selection, scaffold hopping, bioavailabilty,  distribution and solid form optimisation.

Small molecule crystal structures in drug discovery and development

249th National Meeting (2015)

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