Nitrogen-activated carbon-carbon double bonds, as demonstrated by successful existing works on enamines, have a high potential for the construction of various nitrogen-containing products. In order to expand the application of this class of substrates, we have focused on studying the reactivity of the promising enamide derivatives. Starting from the well-known aza-Diels-Alder reaction, we have gradually been drawn to develop other cycloaddition reactions and more generally an extended range of α,β-difunctionalization methods. This lecture will detail our contribution towards the the development of general approaches toward the synthesis of highly functionalized α,β-substituted amines in the context of an ongoing study towards the synthesis of various biologically active natural and non-natural products.<br/><br/>

Straightforward strategies to access N-containing structure: Organocatalysis for the benefit of natural products

249th National Meeting (2015)

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