Triptolide has been isolated from the Chinese medicinal plant <i>Tripterygium wilfordii</i> Hook f. known as the “Thunder God Vine” that has a long history of medicinal value.<br/><br/>Synthesis of such models will require preparative, chiral HPLC and NMR and they will be a starting point for the development of practical medicinal agents, with variations in stereochemistry and functionality. These could be used to develop a structure-activity correlation which might help to clarify the mechanism of action and receptor characteristics involved in the biological response.

Synthesis of diepoxy- and triepoxy c-ring analogs of triptolide: An antileukemic, male contraceptive and an anti-inflammatory diterpenoid triepoxide

249th National Meeting (2015)

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