Transport of medium size molecules through the membrane of living biological cells has been studied in real-time by a combination of Bright-Field Microscopy and the surface sensitive technique Second Harmonic Light Scattering. The effects of molecular structural factors such as polarity and charge, membrane structural factors such as packing of the lipid bilayer and membrane proteins, and the composition of the electrolyte in which the cells live in, on the transport rate are characterized through examining the adsorption/transport of malachite-green (MG), crystal-violet (CV), and bromocresol purple (BCP), charged or neutral hydrophobic molecules, at membranes of Gram-negative and Gram-positive bacteria, and the Murine erythroleukemia (MEL) cells in BPS or aqueous solutions with various salt concentrations.

Molecular transport through living cell membranes: Effects of molecular structure, membrane structure, and electrolyte composition

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.