Synthesis of novel triazole-fused vinyl sultams via utilization of intramolecular C-arylation of triazoles is reported. The use of intramolecular C-arylation on triazoles is relatively under explored. In this regard, we are investigating a versatile “Click-Click Cyclize” method for rapidly assembly of an array of diverse triazole-fused vinyl sultams. Several Pd-catalysts have been screened to optimize the intramolecular C-arylation reaction. Taken collectively, this facile method has been developed for generating novel electrophilic probes for screening.

C-Arylation of triazoles: Synthesis of novel vinyl triazole-fused sultams

249th National Meeting (2015)

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