Transition metal catalyzed C-H activation represents an effective and efficient method for the construction of nitrogen-containing heterocycles. Our work focuses on the formation of γ-lactams using donor/acceptor diazo compounds as one-carbon coupling components. Under mild conditions, a wide variety of benzamides and diazo compounds participate to deliver lactams which bear a synthetically difficult quaternary carbon center.1 Current work is focused on extending this chemistry to a first-row transition metal complex. 1. Hyster, T. K.; Ruhl, K. E.; Rovis, T. J. Am. Chem. Soc. 2013, 135, 5364-5367.

Synthesis of N-heterocycles via transition metal-catalyzed C-H activation

249th National Meeting (2015)

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