Titanium is a key biomedical material used for surgical implants, due to its biocompatibility, high strength, low density, corrosion resistance, and non-toxicity to the host. However, titanium implants can be infected by Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Biofilms formed by microbial colonies can be resistant to antimicrobial treatments. Nitric oxide can be a biofilm dispersant by inducing nitrosative and oxidative stress on the bacteria, transitioning sessile biofilm cells to free swimming planktonic cells, which are more susceptible to antimicrobial treatments. It is hypothesized that the oxidized surface of titanium can be modified with a self-assembled monolayer containing a functional group that releases nitric oxide under physiological conditions. Diffuse Reflectance Infrared Fourier Transform spectroscopy and contact angle measurements were used to analyze the change in the organization of the monolayer on the surface. These substrates were then be modified for nitric oxide release using nitrosoamines.

Reduction of infectious biofilms on the native oxide surface of titanium

249th National Meeting (2015)

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Reduction of infectious biofilms on the native oxide surface of titanium<br />