During this presentation, I will provide an overview of my industrial experience at Dow AgroSciences, paying particular attention the discovery of novel crop protection solutions. Throughout my career, I have contributed to the product pipeline by advancing new compounds. One example of this, has been the quest for new fungicides. Cereals continue to be the key fungicide market, with wheat being the single most important crop, and are a highly concentrated business in Germany, France and the UK. Septoria tritici is most important disease in the cereal market, and there is a desperate need for a highly robust new mode of action for the control of Septoria tritici. The aminopyrimidines are highly active against this commercially important wheat pathogen, Septoria tritici, and act via a novel mode of action. This talk will focus on the discovery and synthetic strategy the team developed to 1) efficently investigate the structure activity relationship (SAR) in an attempt to further increase activity and/or spectrum, 2) establish a patent estate for the aminopyrimidines and 3) identify a second generation compound with unexpected or new attributes while maintaining high Septoria tritici potency. I received a bachelor’s degree in chemistry from Boston University and a Ph.D. in organic chemistry from the University of California, Davis. I currently lead the Process Chemistry group, in Actives to Products at Dow AgroSciences R&D, located in Indianapolis, IN.

Overview of the discovery of a potent Septoria tritici fungicide

249th National Meeting (2015)

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