Metal oxide nanoparticles are a new class of inorganic nanomaterials whose studies and applications in biology and medicine have rapidly expanded over the past decades. Our research lab have prepared and characterized a wide variety of metal oxide nanomaterials conjugated with small fluorescent molecules as potential biocompatible optical probes for molecular imaging. In this presentation, we will discuss cytotoxic assays of TiO<sub>2</sub> and BaTiO<sub>3</sub> nanoparticles covalently labeled with small fluorescent molecules on glioblastoma and melanoma cells. Our results reveal that some of the titanium oxide nanoconjugates are essentially non-cytotoxic over periods of up to 72 hours. We also employed confocal fluorescence microscopy to track cellular internalization of these nanoparticles. Detailed studies and fluorescence images suggesting how the fluorescent nanoconstructs may interact with these model cells will be further addressed.

Studies of cytotoxicity and cellular internalization of small-molecule conjugates of metal oxide nanoparticles in tumor cells

249th National Meeting (2015)

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