Core-shell nanoparticles are significant due to their highly functional applications in modifying antibiotic properties. This work focuses on the development of a simple strategy to produce ZnO/Au, ZnO/Ag, MgO/Au and MgO/Ag core-shell nanoparticles. For the gold shell formation we used HAuCl4·3H2O and AgNO3 for the silver shell formation. Optical properties and characterization of the core-shell was performed by using UV-Vis absorption Spectroscopy and Diffracted Light Scattering (DLS). The size of the ZnO nanoparticles was 35nm, and the core-shell obtained was 270nm for ZnO/Au and 285nm for ZnO/Ag. The size of the MgO nanoparticles was 68nm, and the core-shell obtained was 261nm for MgO/Au and 278nm for the MgO/Ag. Vancomycin and Penicillin antibiotics were used for interaction with core-shell nanoparticles. UV-Vis analysis showed new peaks formation between 275nm to 300nm. Subsequent additions of 20µl up to 180µl total of antibiotics had an increase uptake. Red shift in the 275 nm band absorption occurred for 200-420µl additions; where the peak became sharpened. DLS analysis showed a good polydispersity index indicating uniformity of the sample.

Synthesis and comparative study of ZnO/Au, ZnO/Ag, MgO/Au, and MgO/Ag core-shell nanoparticles with their functionalization with antibiotics

249th National Meeting (2015)

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