Aspergillus flavus is a pathogenic fungus that affects many different agricultural crops in the United States including grains, legumes, and tree nuts; and can cause Aflatoxin in higher organisms such as livestock and sometimes human beings. There are few countermeasures to avoid the growth of A.flavus on grains and even protective means for trees. The goal of this study is to develop novel compounds derived from Ferulic acid as possible fungicides to treat A.flavus growth. A series of compounds were synthesized via a two-step process that includes reduction and replacement reactions. All products were purified by Flash Column Chromatography and structures were determined using Nuclear Magnetic Resonance Spectroscopy (NMR). Collaborators at the USDA-ARS Plant Mycotoxin Research group in California will evaluate these novel compounds for fungicidal activity.

Derivatives of ferulic acid

249th National Meeting (2015)

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