As part of an investigation in search of natural product based agrochemicals and mosquito control agents, ethyl acetate extract of seeds of Ammi visnaga, a member of Apiaceae family was investigated. Plants in Apiaceae family are known to produce secondary metabolites with many biological activities. Bioassay guided isolation of the extract led to the isolation of two furanochromones identified by spectroscopic methods as 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one (1) and 5,8-dimethoxy-2-methyl-4',5'-furano-6,7-chromone (2). When these two compounds were tested on seed germination bioassay at 1mg/mL, (2) showed a higher phytotoxicity on monocots with 100% inhibition than on dicots. (1) was less active. These two compounds showed mosquito larvicidal activity for Ae.aegypti. Compound (2) showed 100% mortality at 0.25 µg/µL whereas (1) had only 40% mortality at the same concentration for 1st instar larvae. These compounds were not active as adulticides when tested topically on Ae.aegypti adults.

Phytotoxic and mosquito larvicidal constituents from Ammi visnaga seeds

249th National Meeting (2015)

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Phytotoxic and mosquito larvicidal constituents from Ammi visnaga seeds<br />