12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo[4,5]cyclohepta[1,2-b]naphthalene-5,12-imine, a novel napthoquinone known as TU100, has shown potential as a chemotherapeutic agent, in part due to its cytotoxic properties in cancerous cells. Past research indicates that this cytotoxic mechanism involves the increased generation of reactive oxygen species (ROS), leading to apoptosis. Ascorbic acid is a common dietary supplement that participates in redox reactions and may interact with TU100 via a redox cycling mechanism, thus enhancing its effect. Stains that fluoresce in the presence of ROS indicate that TU100 and ascorbic acid demonstrate strong cooperativity in the production of these moieties. Implications for usage in targeted cancer therapy are discussed.

Cooperativity of TU100 and ascorbic acid in the production of reactive oxygen species

249th National Meeting (2015)

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