Metabotropic glutamate receptors (mGluRs) are involved in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory and motor information. Several neurological and psychiatric disorders like Parkinson’s disease, Fragile-X syndrome, depression, schizophrenia and addiction have been linked to derailed signaling pathways associated with mGluRs. Due to the therapeutic benefits of targeting allosteric binding sites of these receptors, a synthetic pathway to new mGluR<sub>5</sub> NAM chemotypes is being investigated in which a new scaffold has been designed. Careful spatial arrangement of substituents and a balance of physicochemical properties required to penetrate the CNS as well as metabolic innocuousness are considered in the design.

Design and synthesis of a new mGluR<sub>5</sub> modulator

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Design and synthesis of a new mGluR5 modulator

Design and synthesis of a new mGluR₅ modulator