A synthesis and chiral resolution of the popular anti-Parkinson’s drug, R-rasagiline (Azilect) was developed in order to introduce the intermediate or advanced chemistry undergraduate to a medically relevant multi-step synthesis. It makes use of concepts found in the undergraduate organic chemistry curriculum, conveniently fits into approximately three 3-hr lab modules and utilizes commonly found equipment and inexpensive commercially available chemicals.

Multistep drug synthesis in the sophomore organic lab: Synthesizing R-rasagiline, a popular Parkinson's drug

249th National Meeting (2015)

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