Ultraviolet visible (UV-vis) spectroscopic analysis of vesicle formation utilizing merocyanin-540 produces a nonstandard nonlinear curve that is difficult to quantify using standard analytical techniques.  Intensity of UV spectra correlates with vesicle formation, but to an unknown degree.  This research uses interpolation methods to determine a function that maps changes in peak intensity to vesicle formation at varying concentrations of n-decylamine, glycerolmonodecanoate, and decanoic acid.  This experiment compares several different interpolation methods against previously published data as well as experimental data generated by the authors.  Lagrange interpolation, peak intensity, peak intensity ratios, Gun method, Whittaker-Shannon interpolation, were used to analyze uv-vis curves.<br/>This research determined the free energy contribution to aggregration of vesicles based on headgroup charge.  It was found that ionic strength heavily impacted charged compounds but played a lesser role in formations of structures using uncharged molecules.<br/>Results of this research impact understanding factors relevant in surfactant usage in oil spill remediation, generation of liposomes for drug development, and origins of life vesicle and cell formation theory.

Analysis of application of interpolation techniques to ultraviolet-visible spectroscopy of critical vesicle concentration

249th National Meeting (2015)

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