This investigation involves the synthesis of several spermidine analogs produced in 95% and 100% ethanol as the solvents. These nucleophilic substitution reactions with alkyl or acyl halides produce bis(ethyl), bis(propyl), bis(butyl), bis(acetyl) and bis(benzyl) sperimidine. In this study, 95% or 100% ethanol solvents were used, allowing for the "greener" production of the polyamine analogs. There are many advantages for using alcohols over traditional volatile organic solvents in synthetic reactions. Alcohols are preferred solvents as they are more environmentally friendly, can be reclaimed or recycled, and reactions are run at lower temperatures. It was also found in this work that the use of 100% ethanol increased the product yield dramatically over other more toxic alcohol solvents used in previous studies in our laboratory.

Synthesis of five spermidine analogs using 95% and 100% ethanol

249th National Meeting (2015)

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