Natural products provide an exceptional source of novel therapeutic agents to help fill our ever growing need for medicinal compounds, most notably antibiotics and chemotherapeutics. Unfortunately, large-scale use of complex natural products is often prevented by a lack of an economical synthetic method. We propose that the essential geometry of natural products can be mimicked by replacing key chiral carbons with a chelated metal. We intend to reproduce the three-dimensional shape of a metabolite of the natural product neocarzinostatin, NCSI-gb, through chelation of a metal to an easily synthesized ligand. Previous work has shown the degree to which steric strain and bite angles influence the resultant geometry of tricyclic tetradentate coordination complexes. We will outline the synthesis of different coordination structures with varying ring systems, and discuss the implications for their shape and stability.

Progress toward synthesizing transition metal complexes to mimic complex natural products

249th National Meeting (2015)

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