Phenazine compounds are found as natural products that are predominately synthesized by <i>pseudomonas</i> bacteria. Preliminary assays have shown that exposure to the supernatant of pseudomonas bacteria causes an inhibitory effect on the La Crosse Virus (LCV). We aim to synthesize phenazine derivatives, both naturally occurring and purely synthetic, that will then be assayed against LCV in order to ascertain whether these phenazines are directly responsible for the observed inhibition. Using phenazine-1-carboxylic acid, a compound produced by <i>pseudomonas</i>, as a starting material, we plan to synthetically modify this compound to provide an array of compounds that will be tested against LCV.

Potential use of phenazine derivatives in the inhibition of the La Crosse virus

249th National Meeting (2015)

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