To date, there is no cure for Alzheimer’s disease (AD), a debilitating neurodegenerative disorder affecting an estimated 5.1 million Americans, because there is a lack of potent medications with suitable blood-brain barrier (BBB) penetrability. Recent research has linked cyclooxygenase-1 (COX-1) to amyloid-beta (Aβ)-induced neuroinflammation, and metals, such as iron and copper, may also play a role in Aβ-associated oxidative damage. Clearly, a multifunctional approach is necessary to treat such a complex disease. As such, COX-1 inhibitors and metal chelators have been explored as potential treatments for AD. In this work, peptoids, or N-substituted glycine polymers, containing polyphenolic arms are linked to anti-inflammatory drugs in order to generate dual-acting AD agents with enhanced BBB penetrability. The synthesis, characterization, and membrane permeability of these novel molecules will be presented.

Design and synthesis of multifunctional peptoid-NSAID conjugates

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.