Creatine is a nitrogenous organic acid compound produced within the liver that, in turn, supplies energy to a variety of cells in the body, specifically the muscles. A study has shown the consumption of creatine with exercise (swimming) had an increase in testosterone serum levels, decrease in serum cortisol, and no response in growth hormones. The purpose of this study was to determine if creatine supplementation without exercise would give a similar response. Twenty-three CD1 male mice were used in this seven-week experiment. One group (n=5) consumed creatine monohydrate (CMH) but did not exercise; the second group (n=7) consumed CMH and exercised; the third group (n=5) did not consume CMH but did exercise while the fourth group (n=6) did not consume CMH and did not exercise. The exercised mice were on a workout schedule like that of a typical human, consisting of a five-day schedule of ten minutes of swimming each day. Serum was collected at three different points in time; week 0, week 3, and week 7. These sera were tested through ELISA for testosterone response and compared between groups and within group (by week) and over the seven-week treatment. Through ANOVA and post-hoc testing, significant differences were found in the levels of the testosterone throughout these 7 weeks.

Effects of creatine supplementation on serum testosterone response in <i>Mus musculus</i>

249th National Meeting (2015)

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Effects of creatine supplementation on serum testosterone response in Mus musculus