Investigation on the properties of fluoro-organic compounds has increased in recent years due to their important applications in the pharmaceutical and agricultural industries. An open question is whether the fluorine atom can form a hydrogen bond with a suitable donor. To investigate this issue I will synthesize (2-fluorophenyl)methanol in three steps: attachment of the Boc protecting group to 2-(hydroxymethol)phenol, fluorination of alcohol, and deprotection of Boc-group. This compound will be used to examine the strength of hydrogen bonding via <sup>1</sup>H-NMR spectroscopy.

Synthesis of (2-fluorophenyl)methanol followed by an investigation of hydrogen bonding via <sup>1</sup>H-NMR

249th National Meeting (2015)

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Synthesis of (2-fluorophenyl)methanol followed by an investigation of hydrogen bonding via 1H-NMR

Synthesis of (2-fluorophenyl)methanol followed by an investigation of hydrogen bonding via ¹H-NMR