Kidney cancer is one of the most common types of cancer in the world, causing approximately 100,000 deaths each year. Current diagnosis techniques of kidney cancer, which usually involves angiography and biopsy, tends to cause pain and discomfort in patients. In an effort to identify useful biomarkers for this disease, some recent studies have shown that 4- hydroxybenzoate, quinolinate, gentisate, ⍺-ketoglutarate, galactitol, N-(2- furoyl)glycine, and fructose can be potentially used for the diagnosis process. In this study, we developed and validated a noninvasive method to separate and quantify these compounds in urine using liquid chromatography- tandem mass spectrometry (LC/MS/MS), with creatine as an indicator for urine dilution.

Quantitative determination of kidney cancer biomarkers in urine by liquid chromatography tandem mass spectrometry

249th National Meeting (2015)

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