Acetylsalicylic acid (aspirin) can cause ulceration of the mucosal lining of the stomach. Nitric oxide is an endogenous compound that inhibits ulcer development. Therefore, taking aspirin in unison with a drug capable of releasing nitric oxide would help alleviate the side effects associated with aspirin. 1,2,5-Oxadiazole-2-oxides, also known as furoxans, have been shown to release nitric oxide in the presence of thiol cofactors. Fuxoran derivatives have also been seen to serve therapeutically as nitric oxide generators <i>in vivo</i>. In this presentation, the results from the synthesis of bis-acetylated dibenzoylfuroxans will be discussed.

Synthesis of 3,4-bis(2-acetoxybenzoyl)-1,2,5-oxadiazole-2-oxide

249th National Meeting (2015)

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