Thiosemicarbazones are versatile ligand species and their associated metal complexes have been shown to effectively catalyze a variety of reactions. This research reports the synthesis of a library of novel tridentate [O, N, S] thiosemicarbazone ligands and their associated palladium(II) complexes which were characterized by X-ray crystallography and NMR spectroscopy. These metal complexes were investigated as catalysts in the Suzuki cross-coupling reactions of aryl boronic acids with aryl halides to form biaryl products under “green” reaction conditions (aqueous solvents at room temperature). An examination into the effect of varying ligand structure on the palladium catalyst during cross-coupling reactions will be discussed.

Investigation of thiosemicarbazone ligands in “green” palladium catalyzed Suzuki cross-coupling reactions

249th National Meeting (2015)

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