Biofilms present a serious challenge in medicine and industry. These aggregate cell colonies are problematic in a wide range of scenarios ranging from cystic fibrosis patients to industrial water tanks. Compounds that can inhibit the growth of these films are needed. This paper reports heterocyclic small molecules with an oxadiazole core that are synthesized and assessed as antibacterial agents. Optimization of the synthetic route is presented, including a cyclodehydration reaction and a Suzuki cross-coupling. This optimized route allows for the synthesis of a small library of compounds. This library was tested against <i>Streptomyces</i> and <i>E. coli</i> strains for biofilm and general cell growth inhibition. Both qualitative and quantitative data are presented.

Oxadiazoles as biofilm and bacterial growth inhibitors

249th National Meeting (2015)

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