Artemisinin-resistant strains of malaria are becoming increasingly frequent, and this constitutes a need for antimalarials that exhibit dissimilar modes of action. Recently Medicines for Malaria Venture, together with GlaxoSmithKline released articles outlining a series of compounds that are potential candidates for the next line of antimalarials. We selected a specific N-alkyl-N-imidazoylylbenzamide compound from a refined listing and began investigating several synthetic approaches to synthesize the target, in hopes of conducting efficacy tests. Herein we outline the synthetic progress achieved in preparing both the parent N-alkyl-N-imidazoylylbenzamide and several of its analogs.

Progress towards N-alkylbenzamides as potential antimalarials

249th National Meeting (2015)

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