A series of four copper complexes containing thiosemicarbazones ligands derived from 6-nitropiperonal were synthesized. The complexes were characterized by elemental analyses and spectroscopic methods. The complexes were investigated for the interaction with DNA via a number of methodologies. From competition experiments with ethidium bromide the complexes presented apparent binding constants in the range (0.82 – 1.2) x 104 M-1 indicating that they are weak intercalators. This result is supported by viscosity studies for a representative member of the group. The interaction with DNA was also examined by electronic absorption titrations, gel electrophoresis (the complexes have exhibited a weak ability to uncoil pBR332 plasmid DNA under irradiation with 365 nm UV light) and cyclic voltammetry. The interaction of the complexes with human serum albumin was also examined by fluorescence spectrophotometry. The binding constants for these interactions were on the order of 103 M-1. Initial results of the interaction between the compounds and various proteins (studied by molecular modeling) will be presented. The results of the assays for the anti-oxidant behavior towards nitric oxide and diphenylpicrylhydrazyl are being also being reported.

Synthesis and characterization of copper-thiosemicarbazone complexes: Interaction with DNA and anti-oxidant behavior

249th National Meeting (2015)

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