Bacterial nanocellulose (BNC) is a promising biomaterial for medical applications. Besides its morphology that mimics the structure of collagen, it is produced at relatively low cost; it is biocompatible and can be used as a carrier in drug delivery systems [1–3]. Wound dressing application can be benefited if BNC is combined with Triticum vulgare aqueous extracts (TVE), a natural product with well-known stimulating and healing properties [4,5]. Therefore, we incorporated TVE in BNC membranes by simple impregnation and evaluated the behavior of the resultant biomaterial for wound dressing as a function of TVE loading. The components were characterized for cyto- and geno-toxicity as well as for their thermo-mechanical properties, gas permeability, biocompatibility and morphology (SEM). The results indicate a tensile Young modulus similar to that of excised human skin (60 to 100 MPa) [6] and an enhanced thermal behavior of system compared to the single components. These characteristics make it suitable as a wound dressing material. Additionally, the microstructure of BNC based on nanoribbons (50-70 nm) is similar to that of collagen, which combined with TVE induces human fibroblasts proliferation on the surface of the biomaterial. References: [1] W. Czaja, A. Krystynowicz, S. Bielecki, and R. M. Brown, “Microbial cellulose-the natural power to heal wounds.,” Biomaterials, vol. 27, no. 2, pp. 145–51, Jan. 2006. [2] L. Fu, J. Zhang, and G. Yang, “Present status and applications of bacterial cellulose-based materials for skin tissue repair.,” Carbohydr. Polym., vol. 92, no. 2, pp. 1432–42, Feb. 2013. [3] M. Kucharzewski, A. Franek, and S. M. Academy, “Topical treatment of non-healing venous leg ulcers by cellulose membrane,” Phlebologie, vol. 6, no. 1, pp. 147–151, 2003. [4] D. A. Vanden Berghe, Q. R. Yang, J. Tott, and A. J. Vlietinck, “Specific Stimulation of Human Endothelial Cells by Triticum vulgare Extract and its Biologically Active Fraction,” Phyther. Res., vol. 7, no. May 1992, pp. 172–178, 1993. [5] J. J. Coutiño-Mata, J. Cuenca-Pardo, and C. D. J. Álvarez-Díaz, “Manejo de las áreas donadoras de injertos de piel tratadas con gasa con Triticum vulgare vs gasa con petrolato,” Cir. Plast., vol. 12, no. 2, pp. 61–64, 2002. [6] A. Ní Annaidh, K. Bruyère, M. Destrade, M. D. Gilchrist, and M. Otténio, “Characterization of the anisotropic mechanical properties of excised human skin.,” J. Mech. Behav. Biomed. Mater., vol. 5, no. 1, pp. 139–48, Jan. 2012.

Functionalization of bacterial nanocellulose membranes with Triticum vulgare for wound dressing applications

249th National Meeting (2015)

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