ENABLING THE TRANSATION OF A PRECLINICAL HYPOTHESIS ABOUT HOW A DISEASE MIGHT BE TREATED TO CLINICAL VALIDATION OF THE CONCEPT IS THE GREAT CHALLENGE OF MEDICINAL CHEMISTRY.  THE HISTORY OF MEDICINAL CHEMISTRY TELLS A REMARKABLE STORY OF SUCCESS IN ACHIEVING THIS GOAL AS WELL AS MANY FAILURES TO REACH THE DESIRED END POINT.  THIS PAPER WILL REVIEW SOME OF THIS HISTORY.

Lessons learned in the practice of medicinal chemistry

249th National Meeting (2015)

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