The development of new ROMP-derived oligomeric soluble/silica/magnetic phosphorus and sulfur-based reagents for application in purification-free diversification protocols is reported. Hybrid Si-ROMP benzylic and heterocyclic phosphates (Si-OBP and Si-OHP), and their corresponding oligomeric triazole phosphate (Si-OTP) derivatives were synthesized as free flowing solids for efficient benzylation and triazolation of various scaffolds. Further advancement has led to magnetic Co/C nanoparticles utilizing surface-initiated ROM polymerization. A magnetic Co/C ROMP-derived benzene sulfonate ester (OBSE) has been synthesized as an alkylating reagent for carboxylic acids, phenols and thiols. Moreover magnetic phosphonyl dichloride (Co/C-OPC<sub>n</sub>) has been synthesized as a new scavenging agent. Further developments of new hybrid magnetic reagents are in progress for their utility in synthetic transformations, facilitated synthesis of small molecules, applications in parallel synthesis and potentially automated technologies.

High-load, hybrid ROMP reagents/scavengers/ligands immobilized on silica and Co/C magnetic nanoparticles for their application in sequestration and parallel synthesis

249th National Meeting (2015)

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