Three-membered nitrogen heterocycles are present in many important compounds with significant biology. Thus the development of new methodology for the synthesis of chiral aziridines is important. Significant advancements have been made in the asymmetric synthesis of aziridines in last two decade. However, methods for the construction of chiral aziridines containing fluorinated substituents is very limited. Therefore, we have developed a new methodology to access highly functionalized CF<sub>3</sub>-substituted aziridines using aza-Michael Initiated Ring Closure (aza-MIRC) reaction of b-b-substituted acrylates with N-nosyloxy carbamates in the presence of chiral Lewis acid catalysts. Results from these studies will be presented.

Aza-MIRC reactions. Asymmetric synthesis of trifluoromethyl substituted aziridines

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.