Our group has developed practical methods for the catalytic functionalization of C-H bonds with a series of main group reagents. These studies have led us to a general strategy of installing a single temporary functional group at the position of a C-H bond. This temporary functionality can then be used to form a range of products from one C-H bond functionalization reaction. This lecture will present a combination of methodology and mechanistic studies that connect these functionalizations with the properties of transition metal complexes and demonstration of the capabilities of these reactions for applications to medicine.

Selective functionalization of alkyl and aryl c-h bonds - installation of temporary functional groups

249th National Meeting (2015)

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