&lt;!--[if gte vml 1]&gt;&lt;v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"&gt; &lt;v:stroke joinstyle="miter"/&gt; &lt;v:formulas&gt;  &lt;v:f eqn="if lineDrawn pixelLineWidth 0"/&gt;  &lt;v:f eqn="sum @0 1 0"/&gt;  &lt;v:f eqn="sum 0 0 @1"/&gt;  &lt;v:f eqn="prod @2 1 2"/&gt;  &lt;v:f eqn="prod @3 21600 pixelWidth"/&gt;  &lt;v:f eqn="prod @3 21600 pixelHeight"/&gt;  &lt;v:f eqn="sum @0 0 1"/&gt;  &lt;v:f eqn="prod @6 1 2"/&gt;  &lt;v:f eqn="prod @7 21600 pixelWidth"/&gt;  &lt;v:f eqn="sum @8 21600 0"/&gt;  &lt;v:f eqn="prod @7 21600 pixelHeight"/&gt;  &lt;v:f eqn="sum @10 21600 0"/&gt; &lt;/v:formulas&gt; &lt;v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/&gt; &lt;o:lock v:ext="edit" aspectratio="t"/&gt;&lt;/v:shapetype&gt;&lt;v:shape id="Picture_x0020_1" o:spid="_x0000_s1026" type="#_x0000_t75" style='position:absolute;left:0;text-align:left;margin-left:0;margin-top:16.1pt; width:108pt;height:149.65pt;z-index:251658240;visibility:visible; mso-wrap-style:square;mso-width-percent:0;mso-height-percent:0; mso-wrap-distance-left:9pt;mso-wrap-distance-top:0;mso-wrap-distance-right:9pt; mso-wrap-distance-bottom:0;mso-position-horizontal:absolute; mso-position-horizontal-relative:text;mso-position-vertical:absolute; mso-position-vertical-relative:text;mso-width-percent:0;mso-height-percent:0; mso-width-relative:page;mso-height-relative:page'&gt; &lt;v:imagedata src="file:///C:\Users\mgrunlan\AppData\Local\Temp\msohtmlclip1\01\clip_image001.png"  o:title=""/&gt; &lt;w:wrap type="tight"/&gt;&lt;/v:shape&gt;&lt;![endif]--&gt;&lt;!--[if !vml]--&gt;&lt;!--[endif]--&gt;There is growing clinical need in both wound healing and tissue engineering for controlled release systems that encapsulate drugs and/or growth factors and provide sustained release in a site-specific manner. Biocompatible, biodegradable nanofibrous scaffolds with their morphological similarities to the natural extracellular matrix (ECM) in vivo, high surface area to volume ratio, and small interfibrous pore sizes hold great potential for this application. Loading dopants within an electrospun polymeric matrix allows for consistent entrapment throughout the nanofibers. Further, the high surface area to volume ratio of these matrices maximizes the interaction of the carrier with a surrounding medium. A critical parameter for achieving success in controlled release is controlled diffusion of molecules out of the electrospun scaffolds. The drug release characteristics of nanofibrous scaffolds rely on how well the drug is encapsulated inside the nanofibers. These characteristics are critically affected by fiber morphology. In this presentation, Dr. Loboa will discuss approaches in her lab to elucidate and optimize biomimetic fibrous systems for wound healing and regenerative medicine applications.  Focus will be placed on regeneration of skin and musculoskeletal tissues and approaches to wound care and tissue regeneration while combating multi-drug resistant bacteria.

Addressing infection while engineering biomimetic tissues

249th National Meeting (2015)

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