The synthesis of nucleoside, and analogues thereof, will be presented. One of the approaches developped is based on the stereoselective construction of acylic molecules possessing a nucleobase at their C1’-terminal end, which undergo kinetically controlled cyclization reactions. Diastereoselective free radical based reactions will also be described in the course of these synthesis, as the biological properties of lead molecules.

Nucleoside analogs: Synthesis and medicinal chemistry

249th National Meeting (2015)

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